Real Time Pharmacology

WARNING: RISK OF MEDICATION ERRORS AND •  Use caution when administering acetaminophen in patients with the HEPATOTOXICITY following conditions: hepatic impairment or active hepatic disease, in See full prescribing information for complete boxed warning cases of alcoholism, chronic malnutrition, severe hypovolemia, or severe renal impairment (creatinine clearance ≤ 30 mL/min). (5.1) Take care when prescribing, preparing, and administering Acetaminophen • Discontinue acetaminophen immediately at the first appearance of skin Injection to avoid dosing errors which could result in accidental overdose rash and if symptoms associated with allergy or hypersensitivity occur. and death. (5.3) Do not use in patients with acetaminophen allergy. (5.2, 5.4) ----------------------------- ADVERSE REACTIONS-- ­ The most common adverse reactions in patients treated with acetaminophen been associated with cases of acute liver failure, at times resulting in liver were nausea, vomiting, h...

Side effects of Ibuprofen: Cardiovascular Risk • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. MOTRIN tablets are contraindicated for treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery. Gastrointestinal Risk  NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events Renal Effects Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom r...