Real Time Pharmacology

  Science is based on hypothesis and testing to confirm the hypothesis.  Increasing barriers of transmission is very important to stop the spread of an infection.  Mutations are common for viruses and effects of most mutations and not clear.  Changes in the spike protein may have effects on severity of disease, transmission and antibody and vaccine interaction.  Real effects need to be studied and confirmed.

  CoronaVac is an inactivated vaccine candidate against COVID-19, created from African green monkey kidney cells (Vero cells) that have been inoculated with SARS-CoV-2 (CN02 strain).  At the end of the incubation period, the virus is harvested, inactivated with β-propiolactone (BPL), concentrated, purified, and finally absorbed onto aluminium hydroxide. The aluminium hydroxide complex is then diluted in a sodium chloride, phosphate-buffered saline, and water solution before being sterilised and filtered ready for injection.  Vaccine is prepared in a Good Manufacturing Practice-accredited facility of Sinovac Life Sciences (Beijing, China) that is periodically inspected by the Chinese National Medical Products Administration committee for compliance.  Vaccine of 3 μg in 0·5 mL of aluminium hydroxide diluent per dose in ready-to-use syringes is administered intramuscularly according to the dosing schedule of either day 0 and day 14, or day 0 and day 28, depending on the...

  https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/hospitalization-death-by-age.html