Real Time Pharmacology

 Stroke patient (69 year old) with low energy levels and tardive dyskinesia What is Co-Q 10? Ubiquinone or Co Q 10  is a vitamin like substance and is a cofactor of an enzyme. It is present in the mitocondrial membranes where it is involved in the energy production.  The most common Coenzyme Q in human mitochondria is Co Q 10 . 'Q'  represents quinone head and 10 refers to the number of isoprene repeats in the tail.  Dietary CoQ 10 -supplementation was associated with demonstrable benefits in CPZ-induced Parkinsonism-like changes in mice. Clinical effects have not been well studied in humans. Meat (10-120 mg/kg) and oils (10-280 mg/kg) are the richest sources of dietary Co Q 10 References: 1.  Onaolapo OJ, Odeniyi AO, Jonathan SO, Samuel MO, Amadiegwu D, Olawale A, Tiamiyu AO, Ojo FO, Yahaya HA, Ayeni OJ, Onaolapo AY. An Investigation of the Anti-Parkinsonism Potential of Co-enzyme Q 10  and Co-enzyme Q 10  /Levodopa-carbidopa Combination in ...

  West Nile virus (WNV) is most commonly spread to people by the bite of an infected mosquito. In humans, disease ranges from asymptomatic infection, seen frequently, to encephalitis/paralysis and death, seen rarely.  Symptoms No symptoms in most people.  Most infected individuals  (8 out of 10) do not experience any symptoms. Fever:  About 1 in 5 infected individuals have a fever with other mild symptoms such as rash, headache, body aches, joint pains, vomiting, and diarrhea Serious symptoms   About 1 in 150 infected individuals develop a severe illness affecting the central nervous system such as encephalitis (inflammation of the brain) or meningitis (inflammation of the membranes that surround the brain and spinal cord) About 1 out of 10  people who develop severe illness affecting the central nervous system die. Y ou can reduce your risk of WNV by wearing long-sleeved shirts, long pants, masks, gloves and goggles  to prevent mosquito b...