Real Time Pharmacology

Acute Lacunar Infarct of PONS: A quarter of all ischaemic strokes (a fifth of all strokes) belong to lacunar type. Lacunar infarcts are  noncortical infarcts,   small infarcts (2–20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons,  caused by occlusion of a single penetrating branch of a cerebral artery. Female 75-year old

Molnupiravir   is a prodrug  of the synthetic nuceloside  derivative N4-hydroxycytidine,  currently tested in a Phase 2/3 trial against SARS-COV-2 that is set to be completed in May 2021. Big question: Molnupiravir is structurally similar to cytarabine, will it also have side effects similar to cytarabine? Cytarabine: References: 1. https://clinicaltrials.gov/ct2/show/NCT04405739 2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/071868s032lbl.pdf 3. https://www.biorxiv.org/content/10.1101/2020.03.30.016485v1.full.pdf