Real Time Pharmacology

Capzasin Hp Arthritis Pain Relief with NDC 41167-75142 is an over the counter drug product  Active ingredient: Capsaicin 0.1 % The term "arthritis" refers to several forms of rheumatic diseases (more than 100 conditions). These conditions often affect the joints  and the tissues surrounding the joints such as muscles and tendons ( swelling and tenderness) .  Some types can affect other parts of the body as well including the skin and internal organs . One of the challenges for someone with arthritis is finding ways to live as normally as possible and improving the quality of life. Capsaicin ointment is one of the inexpensive medications that I have seen to help patients during my practice as a pharmacist.  Chemistry: Capsaicin (8-methyl-N-vanillyl-6-nonenamide), Biosynthesized through two pathways related to phenylpropanoid and fatty acid metabolism.  Place in Therapy: Pain/arthritis    Arthritis - Pain TOPICAL, apply thin film to the affected area 3 t...

 

 Patient is a 90 year old female  Ground level fall, After imaging and assessment, it was determined that the patient suffered a left femoral  neck fracture. Surgical intervention occurred on ________and the patient is WBAT Imaging did state a left inferior malleolar fracture is not excluded but ortho felt it was unlikely. She wears a CPAP. Patient did have some post‐op delirium  Patient has the following PMH: COPD Osteoporosis Ostearthritis, Thrombocytopenia, Hyperlipidemia Asthma, A‐fib‐per patient, GERD, CHF

Apixaban and Atrial fibrillation Clindamycin and RLE cellulitis   Switching from warfarin to apixaban: Discontinue warfarin and start apixaban when the INR is less than 2. Switching from apixaban to warfarin: Discontinue apixaban and start a parenteral anticoagulant plus warfarin 5 mg at the time of the next apixaban dose; discontinue the parenteral anticoagulant when INR reaches a therapeutic range 

FDA use:      Symptomatic  Orthostatic Hypotension 10 mg ORALLY 3 times daily at 3- to 4-hour intervals  L ast dose 3-4 hours before sleeping Renal dosing: Renal impairment: starting dose 2.5 mg After initiation of treatment, Midodrine should be continued only for patients who report significant symptomatic improvement.  Mechanism of Action: Midodrine forms an active metabolite, desglymidodrine, an alpha1-agonist, activates the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.  Desglymidodrine diffuses poorly across the blood-brain barrier, and is not associated with central nervous system effects.  Pharmacological Classification: Vasopressor/Antihypotensive CONTRAINDICATIONS: Midodrine/ ProAmatine® is contraindicated in patients with severe organic heart disease, acute renal disease, urinary retention, pheochromocytoma or thyrotoxicosis.  Midodrine sh...